Which numbers on a prescription label are most critical to match with the NDC on the bottle?

When evaluating the National Drug Code (NDC) on a prescription label, the middle four numbers are critical for proper identification of the specific drug. The NDC is a unique identifier for medications that consists of 10 digits, which are usually grouped to indicate the manufacturer, product, and package size.

The first segment of the code identifies the manufacturer or labeler, while the last segment relates to the package size. However, the middle four digits are particularly important because they specify the exact formulation, strength, and dosage form of the medication. This means that matching these middle four numbers with the NDC on the bottle is essential to ensure that the patient receives the correct medication that aligns with the prescription written by their healthcare provider.

For instance, even if the manufacturer and packaging information (first two and last four numbers) match, discrepancies in the middle four digits could indicate a different drug formulation or strength, which could result in administering an incorrect medication to the patient, leading to potential harm. Therefore, the middle four numbers provide critical detail necessary for patient safety and correct dispensing practices.